发明名称 MONOCLONAL ANTIBODY DIRECTED AGAINST CD166 AND METHOD FOR PRODUCTION THEREOF
摘要 <p>CD166 is a cell adhesion molecule belonging to an immunoglobulin superfamily that is expressed in an excessive amount on the tumor surface. If an monoclonal antibody specifically binding to the CD166 is obtained, it becomes possible to suppress growth of tumor cells, detect the cells, and supply a therapeutic drug thereto specifically. However, because the CD166 proteins are very similar to each other among mammals, it was not possible to obtain an antibody to human CD166, by immunizing, for example, mice with the human CD166. The antibody was prepared by immunizing mice with a purified avian CD 166 protein. The antibody was found to be adsorbed on human and mouse CD166 proteins in vitro as well as in vivo and to have an action to suppress tumor growth in mice.</p>
申请公布号 EP1956032(A1) 申请公布日期 2008.08.13
申请号 EP20060833466 申请日期 2006.11.28
申请人 JAPAN SCIENCE AND TECHNOLOGY AGENCY;OSAKA PREFECTURE UNIVERSITY 发明人 TSUKAMOTO, YASUHIRO
分类号 C07K16/42;C12N5/10;C12P21/08;G01N33/574;G01N33/577 主分类号 C07K16/42
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