N-acyl-N'-benzyl-alkylendiamino derivatives

摘要

This invention is related to compounds and use of N-Acyl-N'-benzyl-alkylendiamino derivatives of the following general formula (I), wherein A is a straight or branched C₂-C₈ alkyl chain; X is a methylene, oxygen, sulphur or a NR⁷ group; R¹ is a straight or branched C₁-C₈ alkyl or C₃-C₈ alkenylene or C₃-C₈ alkynylene chain, optionally substituted with CF₃, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C₁-C₄ alkyl, halogens, trifluoromethyl, hydroxy or C₁-C₄ alkoxy groups; R², R³ are independently hydrogen, a C₁-C₃ alkyl chain, halogen, trifluoromethyl, hydroxy or C₁-C₄ alkoxy groups; R⁴, R⁵ are independently hydrogen or C₁-C₆ alkyl; R⁶ is a hydrogen or a straight or branched C₁-C₈ alkyl or linked to R⁵ can form a five to seven membered lactam; R⁷ is hydrogen or C₁-C₆ alkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role