| 发明名称 |
Substituted 1,4,-di-piperidin-4-yl-piperazine derivatives and their use as neurokinin antagonists |
| 摘要 |
The invention concerns substituted 1,4-di-piperidin-4-yl-piperazine derivatives having neurokinin antagonistic activity, in particular NK<SUB>1 </SUB>antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment of emesis, anxiety, depression, pain, pancreatitis and IBS.
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| 申请公布号 |
US7410970(B2) |
申请公布日期 |
2008.08.12 |
| 申请号 |
US20050527821 |
申请日期 |
2005.03.15 |
| 申请人 |
JANSSEN PHARMACEUTICA, N.V. |
发明人 |
JANSSENS FRANS EDUARD;SOMMEN FRANCOIS MARIA;DE BOECK BENOIT CHRISTIAN ALBERT GHISLAIN;LEENAERTS JOSEPH ELISABETH;VAN ROOSBROECK YVES EMIEL MARIA;DIELS GASTON STANISLAS MARCELLA |
| 分类号 |
A61K31/496;A61K31/497;C07D211/58;C07D401/00;C07D401/14;C07D403/00;C07D403/14;C07D405/00;C07D405/14;C07D409/00;C07D409/14;C07D413/14;C07D417/14;C07D471/04 |
主分类号 |
A61K31/496 |
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