发明名称 |
Combination of fenofibrate and coenzyme q10 for the treatment of endothelial dysfunction |
摘要 |
The present invention relates to a combination of a peroxisome proliferator activated receptor (PPAR) activator and a benzoquinone and their use in treating and/or preventing disorders characterized by endothelial dysfunction, such as cardiovascular disease, strokes and myocardial infarction. According to a preferred embodiment of the invention the benzoquinone or precursor thereof is a ubiquinone or precursor thereof, more preferably, coenzyme Q<SUB>10 </SUB>or a precursor thereof, and the PPAR activator is a fibrate or a thiazolidinedione, more preferably fenofibrate.
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申请公布号 |
US7410983(B2) |
申请公布日期 |
2008.08.12 |
申请号 |
US20030399639 |
申请日期 |
2003.04.17 |
申请人 |
FOURNIER LABORATORIES IRELAND LIMITED |
发明人 |
WATTS GERALD FRANCIS;PLAYFORD DAVID ALAN |
分类号 |
A61K31/44;A61K47/20;A61K31/12;A61K31/122;A61K31/215;A61K31/216;A61K31/235;A61K45/00;A61P3/06;A61P3/10;A61P7/08;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P9/14;A61P39/06;A61P43/00 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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