| 摘要 |
A method for preparing a microbead of a hyaluronic acid derivative is provided to produce the microbead of the hyaluronic acid derivative efficiently through a high efficient reaction and a simple recovery process using a small amount of a crosslinking agent, the microbead showing excellent bio-compatibility, excellent swellability and excellent physical stability, thereby the microbead being usefully used as a filler, an implant, a drug delivery matrix, a cell carrier, a scaffold, and an agent for improving joint function. To prepare a microbead of a hyaluronic acid derivative, a hyaluronic acid or an alkaline aqueous solution of a salt thereof is crosslinked with an oil layer using 1,4-butandiol diglycidyl ether(BDDE) as a crosslinking agent with mixing. A microbead of hyaluronic acid derivatives for medical purpose is prepared by the method and is able to be sterilized at a temperature of 121 deg.C. Further, the oil is natural oil, synthesis oil or mineral oil, and has 10 to 500 cP of viscosity.
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