发明名称 |
Micronized crystalline tiotropium bromide |
摘要 |
A novel crystalline, micronized form (I) of tiotropium bromide (TTB) has particle size X50 of 1-3.5 Microm, a Q(5.8) value of more than 60%, a specific surface of 2-5 m2>/g, a specific heat of solution of more than 65 Ws/g and a water content of 1-4.5%. Independent claims are also included for: (1) the production of (I); (2) medicaments (specifically inhalable powders) containing (I); (3) preparation of inhalable powders; and (4) capsules (inhalettes') containing inhalable powders. - ACTIVITY : Antiasthmatic; antiinflammatory. - MECHANISM OF ACTION : Anticholinergic. |
申请公布号 |
HK1078871(A1) |
申请公布日期 |
2008.08.08 |
申请号 |
HK20050110949 |
申请日期 |
2005.12.01 |
申请人 |
BOEHRINGER INGELHEIM PHARMA GMBH & CO KG |
发明人 |
BENDER HELMUT;GRAEBNER HAGEN;SCHINDLER KONRAD;TRUNK MICHAEL JOSEF FRIEDRICH;WALZ MICHAEL |
分类号 |
C07D;A61K;A61K9/00;A61K9/14;A61K9/48;A61K9/72;A61K31/40;A61K31/46;A61K47/02;A61K47/10;A61K47/26;A61K47/36;A61P;A61P11/00;A61P11/06;A61P43/00;C07D451/10 |
主分类号 |
C07D |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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