| 摘要 |
#CMT# #/CMT# A digalactolipid antigen (I) or an antibody directed against (I) is used to prepare a reagent for diagnosing, or a vaccine or medicament for preventing or treating, an apicomplexan parasite infection in humans or animals. #CMT# : #/CMT# Independent claims are also included for: (1) detecting an apicomplexan parasite infection by contacting a biological sample with (I) or an antibody directed against (I) and detecting any antigen-antibody complexes formed; (2) pharmaceutical composition comprising an antibody directed against (I); (3) immunogenic composition or vaccine comprising (I); (4) antibody directed against (I). #CMT#ACTIVITY : #/CMT# Protozoacide. #CMT#MECHANISM OF ACTION : #/CMT# Vaccine. #CMT#USE : #/CMT# Preparing a reagent for diagnosing, or a vaccine or medicament for preventing or treating, an apicomplexan parasite infection in humans or animals, especially an infection caused by a Plasmodium, Babesia, Toxoplasma, Neospora, Cryptosporidium, Theileria, Sarcocystis, Eimeriaor Gregorinapathogen. #CMT#PHARMACEUTICALS : #/CMT# Preferred Antigen: (I) is of formula (Ia), especially a 1,2-diacyl-(alpha -D-galactopyranosyl-(1'-6')-beta -D-galactopyranosyl-(1'-3))-sn-glycerol. R 1OCH 2-CHOR 2-CH 2(O-galactose-CH 2) 2-R 3(Ia) R 1, R 210-25C alkyl or acyl, especially linolenyl; R 3OH or sulfonate. Preferred Antibody: This is a monoclonal, polyclonal or chimeric antibody or a Fab, Fv or short-chain Fv antibody fragment. #CMT#EXAMPLE : #/CMT# Digalactosyldiacylglycerol (DGDG) isolated from spinach chloroplasts was used to immunize rabbits. Serum from the rabbits contained antibodies that recognized DGDG of spinach, Toxoplasmaand Plasmodium. |
