发明名称 |
MODULATORS OF SCLEROSTIN BINDING PARTNERS FOR TREATING BONE-RELATED DISORDERS |
摘要 |
<p>The present invention relates to the use of modulators of the sclerostin: sclerostin- binding-partner interaction for the treatment, amelioration, and diagnosis of sclerostin-related disorders, e.g., osteoporosis and sclerosteosis, and sclerostin-related disorders, e.g., cancers and cardiovascular disorders. The invention also relates to the use of sclerostin-binding-partner mimetics for the treatment, amelioration, and diagnosis of sclerostin-related disorders. Assays for the identification of modulators of the sclerostin: sclerostin-binding-partner interaction, as well as the resulting signaling, are also provided.</p> |
申请公布号 |
WO2008092894(A1) |
申请公布日期 |
2008.08.07 |
申请号 |
WO2008EP51128 |
申请日期 |
2008.01.30 |
申请人 |
NOVARTIS AG;LU, CHRIS XIANGYANG;HU, SHOU-IH;KNEISSEL, MICHAELA;HALLEUX, CHRISTINE |
发明人 |
LU, CHRIS XIANGYANG;HU, SHOU-IH;KNEISSEL, MICHAELA;HALLEUX, CHRISTINE |
分类号 |
A61K38/18;A61K39/395;A61P19/10 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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