发明名称 |
Macrolactams by engineered biosynthesis |
摘要 |
Macrolactams are made by feeding aromatic amino acids as replacement starter units to a mutant strain of the geldanamycin-producing microorganism Streptomyces hygroscopicus var. geldanus NRRL 3602, wherein the gene cluster encoding enzymes for the biosynthesis of the natural starter unit 3-amino-5-hydroxybenzoic acid has been deleted.
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申请公布号 |
US2008188450(A1) |
申请公布日期 |
2008.08.07 |
申请号 |
US20080011068 |
申请日期 |
2008.01.23 |
申请人 |
ASHLEY GARY W;MENZELLA HUGO;WEE JANICE LAU;CARNEY JOHN R |
发明人 |
ASHLEY GARY W.;MENZELLA HUGO;WEE JANICE LAU;CARNEY JOHN R. |
分类号 |
A61K31/395;A61P35/00;C07D225/06;C12N5/00;C12P17/10 |
主分类号 |
A61K31/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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