发明名称 |
Protein and Preventive/Remedy for Neurodegenerative Diseases Such as Polyglutamine Diseases by Utilizing the Same |
摘要 |
To provide a novel protein that can be a preventive/remedy in neurodegenerative diseases such as polyglutamine diseases based on the finding obtained by revealing the relationship between transcriptional dysfunction and neuronal death. Disclosed is a protein that is one of the following proteins (a) and (b). (a) A protein including an amino acid sequence represented by any one of SEQ ID NOS: 1 to 3. (b) A protein including an amino acid sequence in which one to several amino acids are deleted, substituted or added in the amino acid sequence of (a), the protein having a dominant negative effect on a transcriptional activation factor YAP.
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申请公布号 |
US2008188408(A1) |
申请公布日期 |
2008.08.07 |
申请号 |
US20050791053 |
申请日期 |
2005.11.16 |
申请人 |
TOKYO MEDICAL AND DENTAL UNIVERSITY |
发明人 |
OKAZAWA HITOSHI |
分类号 |
A61K38/16;A61P25/28;C07H21/00;C07K14/00;C12N1/21;C12N15/64 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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