<p>A method for determining the risk of a mother of a fetus to develop preeclampsia during pregnancy comprising: (a) providing a sample of genomic DNA from an individual related to the fetus; (b) analyzing the DNA for the presence of one or more mutations in the PP13 gene; and (c) determining the risk of the mother on the basis of the presence of the mutations. Also disclosed are mutated PP13 protein variants, and a kit for use in the method of the invention comprising DNA probes for specific genomic sequences of the PP13 native gene and/or mutated sequences thereof.</p>
