发明名称 |
REGULATION OF LITAF MODULATED CYTOKINE PRODUCTION BY A NOVEL P53 SHORT PEPTIDE |
摘要 |
The present invention relates to a novel isolated and purified peptide of the sequence KQSQHMT [SEQ ID NO: 1], nucleic acid sequences encoding said peptide sequence and capable of expressing said sequence as an exogenous protein in a target cell; as well as methods for the reduction or inhibition of LITAF activity by transfecting the peptide KQSQHMT [SEQ ID NO: 1] or a nucleic acid capable of expressing said peptide, into a target cell. The present invention also relates to the use of the novel peptide (and corresponding nucleotide sequences) of the present invention for the regulation of cytokine expression in target cells. The present invention also relates to the use of the novel peptide (and corresponding nucleotide sequences) of the present invention for the regulation of inflammatory responses in mammals. |
申请公布号 |
WO2008021160(A3) |
申请公布日期 |
2008.08.07 |
申请号 |
WO2007US17687 |
申请日期 |
2007.08.09 |
申请人 |
TRUSTEES OF BOSTON UNIVERSITY;SALOMON, AMAR;XIAOREN, TANG |
发明人 |
SALOMON, AMAR;XIAOREN, TANG |
分类号 |
C07K14/47;A61K38/00;A61K48/00;C07K16/18;C12N15/09 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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