| 发明名称 |
ASSAYS FOR MODULATORS OF PARKIN ACTIVITY USING NOVEL SUBSTRATES |
| 摘要 |
The invention provides in vitro and cell-based assays for parkin activity , in which parkin- mediated ubiquitination of the S5a subunit of the 26S pro teasome is measured, or ubiquitination of troponin 1. The assays may be used to screen for agents that modulate parkin protein ligase activity.
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| 申请公布号 |
CA2677231(A1) |
申请公布日期 |
2008.08.07 |
| 申请号 |
CA20082677231 |
申请日期 |
2008.01.31 |
| 申请人 |
ELAN PHARMACEUTICALS, INC. |
发明人 |
JOHNSTON, JENNIFER A.;GOLDBERG, ALFRED |
| 分类号 |
C12Q1/25;G01N33/50 |
主分类号 |
C12Q1/25 |
| 代理机构 |
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