NOVEL ANSAMYCIN DERIVATIVES AND THE METHOD FOR MUTATIONAL BIOSYNTHESIS THEREOF

摘要

The present invention relates to a method for producing ansamycin derivatives by using a mutant strain with the mutation of 3-amino-5-hydroxylbenzoic acid (AHBA) biosynthesis gene, more precisely a method for producing novel ansamycin derivatives by adding various types of AHBA analogs to the growth medium of the transformant with the mutation of an AHBA biosynthesis gene. Ansamycin derivatives produced by the method of the present invention have ansamycin-like Hsp90 inhibitory effect, so that it can be effectively used as antibiotics, antifungal agents, antiviral agents, immunosuppressants, anti-inflammatory agents or anticancer agents.