发明名称 |
PHOSPHORSÄURESALZ EINES DIPEPTIDYLPEPTIDASE-IV-INHIBITORS |
摘要 |
The dihydrogenphosphate salt of 4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine is a potent inhibitor of dipeptidyl peptidase-IV and is useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as type 2 diabetes. The invention also relates to a crystalline monohydrate of the dihydrogenphosphate salt as well as a process for its preparation, pharmaceutical compositions containing this novel form and methods of use for the treatment of diabetes, obesity, and high blood pressure. |
申请公布号 |
DE602004008938(T2) |
申请公布日期 |
2008.08.07 |
申请号 |
DE20046008938T |
申请日期 |
2004.06.18 |
申请人 |
MERCK & CO. INC. |
发明人 |
CYPES, STEPHEN HOWARD;CHEN, ALEX MINHUA;FERLITA, RUSSELL R.;HANSEN, KARL;LEE, IVAN;VYDRA, VICKY K.;WENSLOW, ROBERT M. |
分类号 |
C07D487/04;A61K31/498;A61K31/4985;A61P3/10 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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