NON-NATURAL AMINO ACID POLYPEPTIDES HAVING MODULATED IMMUNOGENICITY
摘要
The present invention addresses, among other things, modulating the immunogenicity of polypeptides by substituting one or more non- naturally encoded amino acids for any one or more naturally occurring amino acids in the polypeptide or adding a non-natural amino acid, and also addresses the production of polypeptides with improved biological or pharmacological properties, such as improved therapeutic half-life or modulated immunogenicity.
申请公布号
WO2007094916(A3)
申请公布日期
2008.08.07
申请号
WO2007US01485
申请日期
2007.01.18
申请人
AMBRX, INC.;KIMMEL, BRUCE, E.;SIM, BEE-CHENG;DANIEL, THOMAS, O.
发明人
KIMMEL, BRUCE, E.;SIM, BEE-CHENG;DANIEL, THOMAS, O.