| 摘要 |
A method of assaying impaired delayed rectifier potassium current function is disclosed. One or more electrocardiogram (ECG) signals are obtained. One or more heart rates corresponding to a plurality of beats of the one or more ECG signals are obtained. One or more T-wave amplitudes are determined corresponding to one or more beats of the one or more ECG signals. A determination is made whether the one or more T-wave amplitudes as a function of the one or more heart rates are relatively independent of the corresponding one or more heart rates, thereby indicating impaired delayed rectifier potassium current function. An associated biomarker, system, and method for determining the ability of a pharmacological agent to impair delayed rectifier potassium current function are also disclosed.
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