NANOSCALE DNA DETECTION SYSTEM USING SPECIES-SPECIFIC AND/OR DISEASE-SPECIFIC PROBES FOR RAPID IDENTIFICATION THEREOF
摘要
<p>A method and system for detecting a DNA strand using carbon nanotubes or nanowires. A specific single strand of template DNA serves as a probe for its complementary strand in a solution containing DNA segments to be tested. The single-stranded sequence- specific DNA probe segment, whose ends are modified with amine, is attached between two carbon nanotubes/nanowires. When complementary strands representing DNA segments under test are brought near the probe strands, a dielectrophoresis (DEP) field may enhance the probability of selective hybridization between the complimentary target DNA and probe DNA. A change in electrical conductance in the probe strand occurs upon hybridization of the complementary target DNA with the single probe strand. This conductance change may be measured using the two carbon nanotubes or nano-dimensional electrodes. By exploiting nano-dimensional electrodes and single strand probe DNA, the proposed system is capable of accurately detecting a single molecule of DNA.</p>
申请公布号
WO2008094980(A2)
申请公布日期
2008.08.07
申请号
WO2008US52422
申请日期
2008.01.30
申请人
THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES;CHOI, WONBONG;ROY, SOMENATH;MATHEE, KALAI;PRASAD, VISHWANATH