Methods of potentiating opioid-induced analgesia in a subject by administration of a phosphodiesterase (PDE) inhibitor or glial attenuator are described. In particular, the present invention is directed to methods of treating or preventing acute or subchronic pain by administration of a PDE inhibitor or glial attenuator, such as ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine), in combination with an opioid.
申请公布号
WO2008094571(A1)
申请公布日期
2008.08.07
申请号
WO2008US01187
申请日期
2008.01.29
申请人
AVIGEN, INC.;THE REAGENTS OF THE UNIVERSITY OF COLORADO;JOHNSON, KIRK, W.;WATKINS, LINDA;HUTCHINSON, MARK