SEMISYNTHESIS OF PACLITAXEL AND DOCETAXELSEMISYNTHESIS OF PACLITAXEL AND DOCETAXELSEMISYNTHESIS OF PACLITAXEL AND DOCETAXELSEMISYNTHESIS OF PACLITAXEL AND DOCETAXEL
摘要
<p>A semisynthesis of paclitaxel and docetaxel which comprises condensating side chain of chiral trans four-membered rings and protected 10-deacetylbaccatin(10-DAB), allowing the 2'-chirality turnover, then deprotecting the side chain and finally obtaining paclitaxel or docetaxel by removing protective groups. The present method is mild in reaction conditions and is suitable for commercial process.</p>
