Method to diminish cd83 expression in monocyte-derived dendritic cells, t-cells and b-cells by RNAi

摘要

The present invention provides a RNAi method for the specific reduction of CD83 surface expression by dendritic cells (DCs), T-cells and B-cells, especially by DCs. This method can be used to inhibit the T cell activating ability of DCs and for reduction or suppression of T-cell proliferation in immune response. The invention further provides a RNAi agent targeted to the CD83 transcript and dendritic cells obtainable by the method. A method and a medicament for the treatment of a clinical condition which is based on the negative effect of a CD83 mediated interaction between mature DCs and T-cells in a mammalian subject, and a method for decreasing the immunogenicity and rejection potential of a graft using said RNAi agent are also provided.