Free drug particulate form, pharmaceutical composition comprising the same, its use and process for its preparation

摘要

A free drug particulate form of tadalafil in which tadalafil is present as solid particles not intimately embedded in a polymeric co-precipitate, wherein at least 90 % of the particles have a particle size of less than 40 microns. Also described are processes for preparing said drug particulate form, pharmaceutical composition comprising it and its use for the manufacture of a medicament for the treatment of sexual dysfunction, such as male erectile dysfunction or female sexual arousal disorder.