Respiratory syncytial virus replication inhibitors

摘要

The present invention concerns compounds of formula (I), prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof wherein -a¹=a²-a³=a⁴- represents a radical of formula -CH-CH-CH-CH-; -N-CH-CH-CH-; -CH-N-CH-CH-; -CH-CH-N-CH-; CH-CH-CH-N-; wherein each hydrogen atom may optionally be substituted; Q is a radical of formulae (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), wherein Alk is C_1-6alkanediyl; Y¹ is a bivalent radical of formula -NR²- or -CH(NR²R⁴); X¹ is NR⁴, S, S(-O), S(-O)₂, O, CH₂, C(-O), CH(-CH₂), CH(OH), CH(CH₃), CH(OCH₃), CH(SCH₃), CH(NR^5aR^5b), CH₂-NR⁴ or NR⁴-CH₂; X² is a direct bond, CH₂, C(-O), NR⁴, C_1-4alkyl-NR⁴, NR⁴-C_1-4alkyl, t is 2 to 5; u is 1 to 5; v is 2 or 3; and whereby each hydrogen in Alk and in (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), may optionally be replaced by R³; provided that when R³ is hydroxy or C_1-6alkyloxy, then R³ cannot replace a hydrogen atom in the alpha position relative to a nitrogen atom; G is a direct bond or optionally substituted C_1-10alkanediyl; R¹ is an optionally substituted bicyclic heterocycle; R² is hydrogen, formyl, C_1-6alkylcarbonyl, Hetcarbonyl, pyrrolidinyl, piperidinyl, homopiperidinyl, C_3-7cycloalkyl or C_1-10alkyl substituted with N(R⁶)₂ and optionally with another substituent; R³ is hydrogen, hydroxy, C_1-6alkyl, C_1-6alkyloxy, arylC_1-6alkyl or arylC_1-6alkyloxy, R⁴ is hydrogen, C_1-6alkyl or arylC_1-6alkyl; R^5a, R^5b, R^5c and R^5d are hydrogen or C_1-6alkyl; or R^5a and R^5b, or R^5c and R^5d taken together from a bivalent radical of formula -(CH₂)_S- wherein S is 4 or 5; R⁶ is hydrogen, C_1-4alkyl, formyl, hydroxyC_1-6alkyl, C_1-6alkylcarbonyl or C_1-6alkyloxycarbonyl; aryl is optionally substituted phenyl; Het is pyridyl, pyrimidinyl, pyryzinyl, pyridazinyl; as respiratory syncytial virus replication inhibitors; their preparation, compositions containing them and their use as a medicine.