| 摘要 |
The object is to provide a pharmaceutical useful for the remission of a pain caused by ureterolithiasis, the acceleration of removal of a calculus present in the ureter from the body or the like. Disclosed is a therapeutic pharmaceutical for ureterolithiasis, which has a potent inhibitory effect on the contraction of the ureter and comprises an indoline derivative represented by the general formula (I) or a salt thereof as an active ingredient: (I) wherein R represents an aliphatic acyl which may have a substituent and may have an unsaturated bond, a hydroxyalkyl, an aliphatic acyloxyalkyl, a lower alkyl which may have a lower alkoxy, a carboxy, a lower alkoxycarbonyl, an aryl-substituted lower alkoxycarbonyl, a carbamoyl, a monoalkyl-or dialkyl-substituted carbamoyl or a cyano as a substituent, an aromatic acyl which may have be substituted, a furoyl or a pyridylcarbonyl; R1 represents a cyano or carbamoyl; and R2 represents a lower alkyl which may have a halogen, a cyano or a aryl as a substituent. |
