| 摘要 |
The present invention concerns a process for the preparation of a compound of formula 1 or a salt thereof <CHEM> characterised in that the process comprises a) hydroboration of a compound of formula 2 <CHEM> in which formulae A is arylene; R<1> is -C*R<3>R<4>R<5>; R<2> is -O-alkyl, -O-cycloalkyl, -O-alkenyl, -O-aryl, -O-aralkyl, -O-aralkoxyalkyl, -O-alkylsulfonyl, -O-arylsulfonyl, chlorine, bromine or iodine; R<3> is hydrogen; R<4> is aryl; R<5> is alkyl, cycloalkyl, aryl, alkoxyalkyl or hydroxyalkyl; and wherein C* is an asymmetric carbon atom; b) optionally followed by isolation of the desired stereoisomer. |
