MARKER FOR DETECTING LOW-DOSE EXPOSURE TO STEM CELLS, AND METHOD FOR ESTIMATING OR DETECTING LOW-DOSE EXPOSURE TO STEM CELLS USING THE MARKER

摘要

PROBLEM TO BE SOLVED: To provide a method for deducing or detecting influence on stem cells by radiation at low doses of about several mGy levels, to provide a method for predicting the induction of the stem cells to apoptosis that stems from such a low-dose exposure, and to provide a method for screening a substance inhibiting a low-dose radiation inductive cell apoptosis and predicting induction to apoptosis. SOLUTION: The method for determining or detecting the low-dose exposure to a stem cells comprises determining the increase of the expression level of PPP1CA, BAD and/or BCL-XL gene in the stem cells. The method for predicting the induction of the stem cells to apoptosis stemming from such a low-dose exposure is also provided. COPYRIGHT: (C)2008,JPO&INPIT