Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof

摘要

Disclosed are methods for identifying compounds that have a tissue protective activity using a hetero-multimer receptor complex that mediates the tissue protective activities. The complex consists of at least one EPO-R in complex with at least one betac receptor. These compounds used in the assays to identify tissue protective compounds include, but are not limited to, small molecules and biologics. The compounds identified using these assays can be used to treat or prevent various diseases, disorders, or conditions of the central and peripheral nervous systems as well as those of other erythropoietin-responsive or excitable cells, tissues, and organs.