| 摘要 |
A DRUG DELIVERY DEVICE CAN, IN WHOLE OR IN PART, BE FORMED BY CO-EXTRUDING A DRUG CORE AND AN OUTER TUBE(114). THE OUTER TUBE MAY BE PERMEABLE, SEMI-PERMEABLE OR IMPERMEABLE TO THE DRUG. THE DRUG CORE MAY INCLUDE A POLYMER MATRIX WHICH DOES NOT SIGNIFICANTLY AFFECT THE RELEASE RATE OF THE DRUG. THE OUTER TUBE, THE POLYMER MATRIX OF THE DRUG CORE, OR BOTH MAY BE BIOERODIBLE. THE CO-EXTRUDED PRODUCT (112) CAN BE SEGMENTED INTO DRUG DELIVERY DEVICES. THE DEVICES MAY BE LEFT UNCOATED SO THAT THEIR RESPECTIVE ENDS ARE OPEN, OR THE DEVICES MAY BE COATED WITH, FOR EXAMPLE, A LAYER THAT IS PERMEABLE TO THE DRUG, SEMI-PERMEABLE TO THE DRUG, OR BIOERODIBLE.FIG.5
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