发明名称 |
D-amino acid dehydrogenase and method of making D-amino acids |
摘要 |
Polypeptides capable of catalyzing the reductive amination of a 2-ketoacid to its corresponding D-amino acid are provided. The polypeptides can be prepared by mutagenesis of, e.g., a diaminopimelate dehydrogenase. Also provided is a method of making a D-amino acid using a catalytically active polypeptide, wherein a 2-ketoacid is allowed to contact the polypeptide in the presence of a nicotinamide cofactor and ammonia or an ammonia source.
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申请公布号 |
US2008182972(A1) |
申请公布日期 |
2008.07.31 |
申请号 |
US20060391755 |
申请日期 |
2006.03.28 |
申请人 |
ROZZELL J DAVID;NOVICK SCOTT J |
发明人 |
ROZZELL J. DAVID;NOVICK SCOTT J. |
分类号 |
C07C51/00;C07H21/00;C07K14/00 |
主分类号 |
C07C51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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