GENETICALLY RECOMBINANT ANTIBODY COMPOSITION CAPABLE OF BINDING SPECIFICALLY TO GANGLIOSIDE GM2

摘要

Disclosed are: a genetically recombinant antibody composition capable of binding specifically to ganglioside GM2 and having a higher complement-dependent cytotoxic activity than those of a human IgG1 antibody and a human IgG3 antibody, which comprises a human IgG1 antibody having the substitution of a polypeptide containing a CH2 domain in a Fc region therein by a polypeptide comprising an amino acid sequence corresponding to the same region in an human IgG3 antibody as numbered according to the EU index as in Kabat et al.; DNA encoding an antibody molecule contained in the genetically recombinant antibody composition or a heavy-chain constant region of the antibody molecule; a transformant produced by introducing the DNA into a host cell; a method for producing an genetically recombinant antibody composition by using the transformant; and a pharmaceutical agent comprising the antibody composition as an active ingredient.