发明名称 |
METHODS AND KITS FOR DIAGNOSING AND TREATING B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA |
摘要 |
The present invention relates to methods and kits for detecting several polynucleotide sequence found to be indicative of a poor prognosis of B-CLL. All the polynucleotides are transcribed from a region on human chromosome 12p21-22. Most of the polynucleotides do not encode larger polypeptides, but may encode small peptides, they may function as RNAs. Four polynucleotides encode a novel protein, which in one preferred embodiment can be used as a cytokine, preferably as an interleukin. Furthermore the invention relates to methods and compositions for treating B-CLL in particular poor prognosis B-CLL.
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申请公布号 |
US2008181907(A1) |
申请公布日期 |
2008.07.31 |
申请号 |
US20070847936 |
申请日期 |
2007.08.30 |
申请人 |
H:S RIGSHOSPITALET;ARHUS UNIVERSITET |
发明人 |
HERTZ ANNE METTE BUHL;LEFFERS HENRIK;KJEMS JORGEN |
分类号 |
A61K39/00;A61K38/00;A61P43/00;C07H21/00;C07K14/47;C07K14/52;C07K14/54;C07K16/00;C12N15/12;C12Q1/68;G01N33/574 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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