发明名称 |
DIAGNOSTIC METHODS FOR DISEASES BY SCREENING FOR HEPCIDIN IN HUMAN OR ANIMAL TISSUES, BLOOD OR BODY FLUIDS, MONOCLONAL ANTIBODIES SPECIFIC TO HUMAN HEPCIDIN AND ASSOCIATED USES THEREFOR |
摘要 |
<p>The present application concerns antibodies specific for the C-terminus of human hepcidin, and related methods and kits for diagnosing and/or treating a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding to the amino acid sequence between and including amino acids 60 and 84, or, in another embodiment, amino acids 74 and 81, as aligned with the human pre-pro-hepcidin precursor protein, and quantifying the pro-hepcidin and/or mature hepcidin level using an assay based on binding of the antibody and the polypeptide; wherein the non-physiological level of prohepcidin/mature hepcidin is indicative of the disease condition. The present application also concerns diagnostic methods and kits for applications in genetic technological approaches, such as for overexpressing or downregulating hepcidin.</p> |
申请公布号 |
WO2008089795(A1) |
申请公布日期 |
2008.07.31 |
申请号 |
WO2007EP02559 |
申请日期 |
2007.03.22 |
申请人 |
DRG INTERNATIONAL, INC.;KULAKSIZ, HASAN;GEACINTOV, CYRIL E.;JANETZKO, ALFRED |
发明人 |
KULAKSIZ, HASAN;GEACINTOV, CYRIL E.;JANETZKO, ALFRED |
分类号 |
C07K16/26;A61B;A61B1/00;A61K39/395;C07K14/47;C07K14/575;C07K16/18;G01N33/53;G01N33/563;G01N33/577;G01N33/74 |
主分类号 |
C07K16/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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