发明名称 |
Process for the Preparation of Irinotecan Hydrochloride Trihydrate |
摘要 |
The invention relates to an improved process for the preparation of Irinotecan hydrochloride trihydrate of formula (4) of enhanced yield, purity by contacting 1-chlorocarbonyl-4-piperidinopiperidine hydrochloride with 7-ethyl-10-hydroxy-camptothecin [IRT-3 (synthetic)] to obtain crude Irinotecan which is subsequently purified by solvent treatment, obtaining purified irinotecan which is converted into irinotecan hydrochloride trihydrate and the invention also relates to a report of the compound 1-chlorocorbonyl-4-piperidinopiperidine hydrochloride of formula (1) and its process for preparation.
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申请公布号 |
US2008182990(A1) |
申请公布日期 |
2008.07.31 |
申请号 |
US20070573397 |
申请日期 |
2007.09.14 |
申请人 |
SHILPA MEDICARE LIMITED |
发明人 |
VISHNUKANT B.;PUROHIT PRASHANT;PAPARAO K. |
分类号 |
C07D471/22;C07D211/58;C07D491/22 |
主分类号 |
C07D471/22 |
代理机构 |
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