A waveguide handpiece, a system utilizing a waveguide handpiece and methods utilizing the same. The waveguide handpiece has an at least partially hollow elongated tubular member capable of receiving a terminal fiber optic endoprobe such as a hollow waveguide. The waveguide handpiece is capable of use with an apparatus that propagates electromagnetic radiation from a radiation source. The entire waveguide handpiece is suitable for autoclaving, as well as other methods of sterilization, and reuse.