METHOD FOR PRODUCING GRIGNARD REAGENT OF FLUORINE-CONTAINING CHLOROBENZENE COMPOUND IN TETRAHYDROPYRAN AS SOLVENT

摘要

PROBLEM TO BE SOLVED: To provide a method for producing a Grignard reagent from a fluorine-containing chlorobenzene compound and magnesium, by which the product is easily obtained by improving low reactivity of the fluorine-containing chlorobenzene compound at an improved reaction rate and in an improved Grignard reagent yield. SOLUTION: This method for producing the Grignard reagent from the fluorine-containing chlorobenzene compound and the magnesium as raw materials is characterized by using tetrahydropyran as a solvent. COPYRIGHT: (C)2008,JPO&INPIT