发明名称 |
Suppression of Endogenous Immunoglobulin Expression in Non-Human Transgenic Animals |
摘要 |
The invention provides anovel approach for the suppression of endogenous antibody expression in non-human transgenic animals genetically engineered to express one or several human or humanized immunoglobulin transloci. Endogenous immunoglobulin expression in transgenic non-human animals is suppressed by selective expression of a suicide gene like a toxin only in B-cells expressing endogenous immunoglobulin but not in B-cells expressing human(ized) immunoglobulins. This method allows the dominant expression of transloci coding for humanized or human antibodies in the blood, milk and eggs of transgenic animals.
|
申请公布号 |
US2008184380(A1) |
申请公布日期 |
2008.07.31 |
申请号 |
US20050665852 |
申请日期 |
2005.10.21 |
申请人 |
THERAPEUTIC HUMAN POLYCLONALS INC. |
发明人 |
BUELOW ROLAND;PLATZER JOSEF |
分类号 |
A01K67/027;C12N15/00;C12N15/53 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|