PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE a-FLUOROCARBOXYLATE ESTER

摘要

An optically active a-fluorocarboxylate ester can be produced by reacting an optically active a-hydroxycarboxylate ester with sulfuryl fluoride (SO₂F₂), trifluoromethanesulfonyl fluoride (CF₃SO₂F) or nonafluorobutanesulfonyl fluoride (C₄F₉SO₂F) in the presence of an organic base and in the absence of a reactive solvent. More preferably, the reaction solution produced after the reaction is completed is added with an acid and is subjected to distillation purification, thereby producing the optically active a-fluorocarboxylate ester with a higher purity. The process enables to produce an optically active a-fluorocarboxylate ester advantageously on a large scale.