发明名称 |
NON-HUMAN ANIMAL FOR EYE DISEASE MODEL |
摘要 |
It is intended to provide an animal model which shows a naturally occurring eye disease symptom, particularly ocular hypertension and/or retinal degeneration. The invention relates to a non-human animal for eye disease model in which the function of Vav2 gene and/or Vav3 gene have/has been impaired. Because the animal shows a naturally occurring eye disease symptom, such as ocular hypertension and/or retinal degeneration without administering a drug or placing it in a special growth environment, it can be used as a model useful for elucidation of onset mechanism of eye disease or evaluation for therapeutic agent for eye disease. When it is applied for such a purpose, because it is not affected by an exogenous factor, which is conventionally administered for artificially inducing eye disease, it reflects a natural pathology, therefore, the clinical and industrial usefulness thereof is high. |
申请公布号 |
WO2008090742(A1) |
申请公布日期 |
2008.07.31 |
申请号 |
WO2008JP00069 |
申请日期 |
2008.01.23 |
申请人 |
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY;FUJIKAWA, KEIKO;INOUE, KAORU |
发明人 |
FUJIKAWA, KEIKO;INOUE, KAORU |
分类号 |
A01K67/027;C12N15/09;G01N33/15;G01N33/50 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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