发明名称 |
CANCEROUS DISEASE MODIFYING ANTIBODIES |
摘要 |
The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating th e anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therape utic and diagnostic purposes. The antibodies can be used in aid of staging a nd diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells.
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申请公布号 |
CA2674897(A1) |
申请公布日期 |
2008.07.31 |
申请号 |
CA20082674897 |
申请日期 |
2008.01.23 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
POPP, LISA A.;HAHN, SUSAN E.;FINDLAY, HELEN P.;YOUNG, DAVID S. F. |
分类号 |
C12N5/18;A61K39/395;A61K47/48;A61K51/10;A61P35/00;A61P37/04;C07K16/18;C07K16/30;C07K16/46;C07K19/00;C12N5/16;C12P21/08;G01N33/574;G01N33/577 |
主分类号 |
C12N5/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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