摘要 |
The present invention is directed to the tosylate salt of trans-N-ethyl-3 - fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)-phenyl]-cyclobutanecarboxamid e Formula (I):to solvates (e.g., hydrates) thereof, to polymorphs thereof, t o pharmaceutical compositions thereof and to a method of treating depression , mood disorders, schizophrenia, anxiety disorders, cognitive disorders, Alz heimer's disease, attention-deficit disorder (ADD), attention-deficit hypera ctivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizz iness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-ind uced airway responses, allergic rhinitis, nasal congestion, allergic congest ion, congestion, hypotension, cardiovascular disease, diseases of the Gl tra ct, hyper- and hypo-motility and acidic secretion of the gastro-intestinal t ract comprising administering a therapeutically effective amount thereof.
|