| 摘要 |
Pharmaceutical formulations are disclosed comprising a multi-phasic pharm aceutical composition comprising an active pharmaceutical ingredient, wherei n the active pharmaceutical ingredient is in a particulate state, a solubili zed state, or in both a particulate state and in a solubilized state; a solv ent; a non-miscible liquid; a stabilizer; and water; wherein the pharmaceuti cal formulation is an oral dosage form. Such pharmaceutical formulations are capable of reducing the fed/fast variability and improving oral bioavailabi lity to which a number of active pharmaceutical ingredients are susceptible. The pharmaceutical formulations of the invention, therefore are bioequivale nt in fed and fasted states and improved oral bioavailability.
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