Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various DNA polymerases and have permitted the detection of rare and subtle mutations in DNA isolated from plasma of cancer patients.
申请公布号
EP1948816(A2)
申请公布日期
2008.07.30
申请号
EP20060817236
申请日期
2006.10.20
申请人
THE JOHNS HOPKINS UNIVERSITY
发明人
VOGELSTEIN, BERT;DIEHL, FRANK;KINZLER, KENNETH, W.;LI, MING