The invention provides butyrylcholinesterase inhibitors of Formula I which contain an heterocyclic moiety and a 4 piperidine moiety with a linker in between. The compounds show a very high activity and selectivity towards BuChE, making them useful for the treatment and or prophylaxis or cognitive disorders and/or neurodegenerative disorders. <CHEM>
申请公布号
ZA200610127(B)
申请公布日期
2008.07.30
申请号
ZA20060010127
申请日期
2005.05.27
申请人
NEUROPHARMA, SA
发明人
MARTINEZ GIL, ANA;RUBIO ARRIETA, LAURA;MUNOZ RUIZ, PILAR;DORRONSORO DIAZ, ISABEL;GARCIA PALOMERO, ESTHER;DEL MONTE MILLAN, MARIA;MEDINA, PADILLA, MIGUEL