An antibody against a receptor for human interleukin - 12 and its use

摘要

The present disclosure is directed to IL-12 receptor proteins comprising a complex of the beta1 receptor protein with the beta2 receptor protein, which complex is capable of binding to human IL-12 with high affinity. When expressed in host cells the nucleic acid gives rise to substantially homogeneous IL-12 receptor proteins. The invention relates to antibodies capable of binding to cells expressing the IL-12 receptor molecules for use in the treatment of an autoimmune dysfunction.