发明名称 |
PROCESS FOR THE PREPARATION OF PIPERIDINYLAMINOMETHYL TRIFLUOROMETHYL CYCLIC ETHER COMPOUNDS |
摘要 |
The present invention relates to a novel process for the preparation of a diastereomeric mixture of piperidinylaminomethyl trifluoromethyl cyclic ether compounds of formulae Ia and Ib: (see formula I and II) and pharmaceutically acceptable salts thereof, wherein R1 is C1-C6 alkyl; R2 is C1-C6 alkyl, halo C1-C6 alkyl or phenyl or substituted phenyl; R3 is hydrogen or halo; m is zero, one or two, and wherein said mixture is highly enriched in the compound of formula Ia, and to novel processes for the preparation and purification of intermediate compounds useful in the preparation of compounds of formulae Ia and Ib.
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申请公布号 |
CA2323315(C) |
申请公布日期 |
2008.07.29 |
申请号 |
CA20002323315 |
申请日期 |
2000.10.16 |
申请人 |
PFIZER PRODUCTS INC. |
发明人 |
CARON, STEPHANE;VAZQUEZ, ENRIQUE |
分类号 |
C07D405/12;A61K31/443;A61K31/453;A61P25/00;A61P25/18;A61P25/24;C07B61/00;C07C41/26;C07C43/23;C07C51/373;C07C59/90;C07C67/08;C07C67/14;C07C67/297;C07C69/16;C07C69/66;C07C69/734;C07C69/738;C07C69/96;C07D211/56;C07D307/87;C07D307/88;C07D311/20;C07D311/76;C07F7/18 |
主分类号 |
C07D405/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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