Anti-inflammatory androstane derivatives

摘要

There are provided compounds of formula (I) wherein R₁ represents O, S or NH; R₂ represents -C(-O)-aryl or -C(-O)-heteroaryl; R₃ represents hydrogen, methyl (which may be in either the alpha or beta configuration) or methylene; R₄ and R₅ are the same or different and each represents hydrogen or halogen; and represents a single or a double bond; and salts and solvates thereof; process for preparing them, compositions containing them and their use in therapy.