发明名称 |
Selectin ligand interactor cytoplasmic (SLIC-1), a P-selectin glycoprotein ligand (PSGL-1) binding protein |
摘要 |
The invention provides isolated nucleic acids molecules, designated SLIC-1 nucleic acid molecules, which encode novel P-selectin glycoprotein ligand (PSGL-1) binding molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLIC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a SLIC-1 gene has been introduced or disrupted. The invention still further provides isolated SLIC-1 proteins, fusion proteins, antigenic peptides and anti-SLIC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
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申请公布号 |
US7405272(B2) |
申请公布日期 |
2008.07.29 |
申请号 |
US20040961070 |
申请日期 |
2004.10.12 |
申请人 |
GENETICS INSTITUTE, L.L.C. |
发明人 |
LORENZ MEIKE;KRIZ RON;WEICH NADINE;SHAW GRAY D. |
分类号 |
C07K14/705;G01N33/50;A61K38/00;C07K14/47;C07K16/18;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12Q1/02;C12Q1/68;G01N33/15;G01N33/53;G01N33/566 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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