发明名称 DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS
摘要 An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group-CH=, R1 represents a group-Z-R6, in which Z represents a group-CO-, a group-CH(OH)-or the like, R6 represents a 5-to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group-O-, a group-CO-, a group-CH(OH)-or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
申请公布号 KR20080070054(A) 申请公布日期 2008.07.29
申请号 KR20087013451 申请日期 2006.12.04
申请人 OTSUKA PHARMACEUTICAL CO., LTD. 发明人 MATSUYAMA HIRONORI;OHNISHI KENJI;NAKAGAWA TAKASHI;TAKASU HIDEKI;SAKAMOTO MAKOTO;HIGUCHI KUMI;MIYAJIMA KEISUKE;YAMADA SATOSHI;MOTOYAMA MASAAKI;KOJIMA YUTAKA;YASUMURA KOICHI;KODAMA TAKESHI;OTSUJI SHUN;KAN KEIZO;SUMIDA TAKUMI
分类号 A61K31/495;A61K31/496;A61P35/00 主分类号 A61K31/495
代理机构 代理人
主权项
地址