| 摘要 |
Pharmaceutical combination, comprises: (A) a composition containing an antidiabetic or anti-hyperlipidemic agent (I); and (B) a composition containing a hydroximic acid derivative (II). Pharmaceutical combination, comprises: (A) a composition containing an antidiabetic or anti-hyperlipidemic agent (I); and (B) a composition containing a hydroximic acid derivative of formula (II). [Image] R 1>H or 1-5C alkyl; R 2>H, 1-5C alkyl, 3-8C cycloalkyl, phenyl, hydroxyphenyl or biphenylyl; R 3>H or a phenyl, naphthyl or pyridyl group (optionally substituted by halogen or 1-4C alkoxy); NR 1>R 2>5-8 membered ring (optionally containing further N, O or S heteroatoms and optionally fused to another alicyclic or heterocyclic ring, where N and/or S heteroatoms are optionally in oxide or dioxide form); Y : H, OH, 1-24C alkoxy (optionally substituted by amino), 2-24C polyalkenyloxy (with 1-6 double bonds), 1-25C alkanoyl, 3-9C alkenoyl or R 7>COO; R 7>2-24C polyalkenyl (with 1-6 double bonds); B : undefined; X : halo, amino or 1-4C alkoxy; or X+B : oxo; or X+Y : 1,2,4-oxadiazine or 4,5-dihydro-1,2,4-oxadiazine; R : H; A : 1-4C alkylene, a bond or (CHR 4>) m-(CHR 5>) n; R 4>H, 1-5C alkyl, 3-8C cycloalkyl or phenyl (optionally substituted by halo, 1-4C alkoxy or 1-5C alkyl); R 5>H, 1-4C alkyl or phenyl; and m, n : 0-2. ACTIVITY : Antidiabetic; Antilipemic. No biological data available. MECHANISM OF ACTION : None given. |
