发明名称 |
HIF-1Alpha; SPECIFIC PROLYL HYDROXYLASE 2 INHIBITORS AND COMPOSITION FOR THE PREVENTION AND TREATMENT OF ISCHEMIC DISEASES CONTAINING THE SAME |
摘要 |
A baicalein screened by analyzing a binding between a fluorescence-labelled HIF-1alpha peptide and a VBC protein as a prolyl hydroxylase 2 inhibitor is provided to be usefully used to prevent or treat ischemic diseases such as coronary artery diseases, brain failure and vascular insufficiency. A prolyl hydroxylase 2 inhibitor composition comprises baicalein as an effective ingredient. A composition for preventing or treating ischemic diseases such as coronary artery diseases, brain failure and vascular insufficiency comprises the baicalein and further comprises at least one additive selected from the group consisting of a pharmaceutically acceptable excipient, a disintegrating agent, a binding agent and a lubricant.
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申请公布号 |
KR20080069384(A) |
申请公布日期 |
2008.07.28 |
申请号 |
KR20070007036 |
申请日期 |
2007.01.23 |
申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
YANG, EUN GYEONG;CHO, HYUN JU;KIM, SUN YUN;PARK, HYUN SUNG |
分类号 |
A61K31/352;A61P9/10 |
主分类号 |
A61K31/352 |
代理机构 |
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